Chloroacetaldehyde → 10-Methyl-9-[2-(1,3-thiazol-2-yl)hydrazinylidene]-9,10-dihydroacridine--hydrogen chloride (1/1)

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Reaction Steps

1.9 g of 10-methyl-9acridanone thiosemicarbazone are suspended in 100 ml of methanol and stirred at 50° for 6 hours with 1.73 ml of chloroacetaldehyde (50percent aqueous solution). The mixture is concentrated, the crystalline product is filtered and washed successively with ethanol, water, ethanol and ether. There is obtained 10-methyl-9-acridanone (2-thiazolyl)hydrazone hydrochloride of melting point 224°-225° (decomposition).

Provenance & Evidence