Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Iodoethane | HCID 6340 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1-Cyclopropyl-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid | HCID 185236 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 70454196 | HCID 70454196 | 46.2% |
Reaction Steps
A mixture of 1.7 g (0.005 mol) of 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(3-methyl-1-piperazinyl)quinoline-3-carboxylic acid, 1.7 g (0.011 mol) of ethyl iodide and 1.1 g of triethylamine in 20 ml of DMF is heated at 80° C. for 3 hours. The solution is evaporated in vacuo, the crystalline residue is stirred thoroughly with 10 ml of water and the undissolved product is recrystallised from methanol. 0.6 g (32% of theory) of 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-ethyl-3-methyl-1-piperazinyl)quinoline-3-carboxylic acid hydriodide monohydrate, with a decomposition point of 285°-288° C., is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04544658 |
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| Source dataset | uspto-grants-1985_10 |
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| ORD ID | ord-daa6ef135a8e472493355b13068493e3 |
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| Source note | uspto-grants-1985_10 |
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