Potassium Carbonate → HCID 13248079, compound

Participants

Reaction Steps

Potassium carbonate (6.0 g.) was added to a solution of 3-benzyloxycarbonyloxy-1-(3,4-dichlorobenzyl)-7-fluoro-2-oxoindoline-3-carboxamide (2.0 g.) in toluene (100 ml.). The mixture was stirred and heated under reflux for 1 hour. The toluene was removed by evaporation and the residue partitioned between ether (100 ml.) and water (100 ml.). The aqueous phase was adjusted to pH 5 with 2M hydrochloric acid. The ether phase was then separated, washed with water, brine and then dried (MgSO4) and evaporated to give 1'-(3,4-dichlorobenzyl)-7'-fluorospiro[oxazolidine-5,3'-indoline]-2,2',4-trione, as a solid, m.p. 140°-142° C. (recrystallised from ethyl acetate/petrol 60-80).

Provenance & Evidence