HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 1-[(5-Amino-1,3,4-thiadiazol-2-yl)amino]-3-[3-(1-piperidinylmethyl)phenoxy]-2-propanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-Amino-5-bromo-1,3,4-thiadiazole | HCID 3650883 | — |
| Reactant | 1-Amino-3-{3-[(piperidin-1-yl)methyl]phenoxy}propan-2-ol | HCID 13189825 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-[(5-Amino-1,3,4-thiadiazol-2-yl)amino]-3-[3-(1-piperidinylmethyl)phenoxy]-2-propanol | HCID 13657366 | — |
Reaction Steps
0.54 g (3 mmol) of 5-bromo-1,3,4-thiadiazole-2-amine and 0.45 ml of triethylamine are added to 0.8 g (3 mmol) of 1-amino-3-[3-(1-piperidinylmethyl)phenoxy]-2-propanol in 20 ml of THF and the mixture is reacted in a manner analogous to Example 51. The oil obtained is purified by column chromatography (silica gel; ammoniacal. Methanolchloroform solution (5+95)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04727081 |
| Source dataset | uspto-grants-1988_02 |
| ORD ID | ord-6a7ed01635ed4c138cea3a4b01da5ca5 |
| Source note | uspto-grants-1988_02 |