反应详情

A mixture containing methylguanidine sulfate (16.52 g), 8.8 g of aqueous sodium hydroxide (50% solution), and 100 ml of acetone, is stirred for 21/2 hrs at RT. Anhydrous sodium sulfate (6.0 g) is added, and stirring continued for 1 hr. A solution of 4-methoxyphenylacetylchloride (9.23 g) in 50 ml of acetone is added dropwise and the reaction mixture stirred overnight at RT. The reaction mixture is filtered and the filtrate diluted with 100 ml of saturated aqueous sodium bicarbonate. The acetone is evaporated in vacuo, and the aqueous residue diluted with 100 ml H2O and extracted with two 100 ml portions of methylene chloride. The combined organic extracts are dried with sodium sulfate, filtered and concentrated in vacuo. The concentrate is acidified with ethereal hydrochloric acid and the solvent evaporated in vacuo. The residue is stirred in 200 ml of diethyl ether. The resultant solid is collected, washed with diethyl ether, dried in air and recrystallized, affording 5.43 g of a white solid, M.P. 125°-128° C.

1. stirringstirring
2. waitcontinued for 1 hr
3. stirringthe reaction mixture stirred overnight at RT
4. filtrationThe reaction mixture is filtered
5. additionthe filtrate diluted with 100 ml of saturated aqueous sodium bicarbonate
6. customThe acetone is evaporated in vacuo
7. additionthe aqueous residue diluted with 100 ml H2O
8. extractionextracted with two 100 ml portions of methylene chloride
9. dry with materialThe combined organic extracts are dried with sodium sulfate
10. filtrationfiltered
11. concentrationconcentrated in vacuo
12. customthe solvent evaporated in vacuo
13. stirringThe residue is stirred in 200 ml of diethyl ether
14. customThe resultant solid is collected
15. washwashed with diethyl ether
16. customdried in air
17. customrecrystallized