HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 5-Methyl-3-phenylisoxazole-4-carbonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 5-Methyl-3-phenyl-4-isoxazoloyl carboxylic acid | HCID 20265152 | — |
| Catalyst | Pyridine | HCID 1049 | — |
| Product | 5-Methyl-3-phenylisoxazole-4-carbonyl chloride | HCID 85624 | — |
Reaction Steps
A mixture of 111.76 g of 5-methyl-3-phenyl-4-isoxazoloyl carboxylic acid, 6 drops of pyridine and 29.5 ml of thionyl chloride is stirred under reflux for 4 hrs. The excess thionyl chloride is evaporated in vacuo. Distillation of the residue yields 113.74 g of yellow liquid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04544670 |
| Source dataset | uspto-grants-1985_10 |
| ORD ID | ord-e5e56676ef5d48e9b65a67a4cd85f5d8 |
| Source note | uspto-grants-1985_10 |