HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(3-Chloro-4-hydroxyphenyl)-2-oxoacetic acid → (1-t-Butoxycarbonylethoxyimino)-2-(3-chloro-4-hydroxyphenyl)acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(3-Chloro-4-hydroxyphenyl)-2-oxoacetic acid | HCID 12961139 | — |
| Reactant | Tert-butyl 2-(aminooxy)propanoate | HCID 19978722 | — |
| Product | (1-t-Butoxycarbonylethoxyimino)-2-(3-chloro-4-hydroxyphenyl)acetic acid | HCID 136081925 | 96.3% |
Reaction Steps
2-(3-Chloro-4-hydroxyphenyl)glyoxylic acid (2.0 g.) and O-(1-t-butoxycarbonylethyl)hydroxylamine (3.2 g.) were reacted according to a similar manner to that of Preparation (5-7) to give 2-(1-t-butoxycarbonylethoxyimino)-2-(3-chloro-4-hydroxyphenyl)acetic acid (syn isomer) (3.3 g.), mp 148° to 151° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04544653 |
| Source dataset | uspto-grants-1985_10 |
| ORD ID | ord-e9b6b9b9207a47bfb8f420e83763b4dc |
| Source note | uspto-grants-1985_10 |