Pyridine → HCID 20265468, compound

HRID 463903Notes

Reaction equation

HRID 463903 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:10]([Cl:13])([Cl:12])[Cl:11])[OH:9])=[CH:4][CH:3]=1.N1C=CC=CC=1.[C:20](OC(=O)C)(=[O:22])[CH3:21]>>[C:20]([O:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:10]([Cl:11])([Cl:12])[Cl:13])[OH:9])=[CH:4][CH:3]=1)(=[O:22])[CH3:21]

Participants

4

Reactant 3

HCID 1049PyridineHCID 7918Acetic AnhydrideHCID 2946145HCID 2946145, compound

Product 1

HCID 20265468HCID 20265468, compoundYield 98.5%

Procedure

A 0.1 mole quantity of p-hydroxyphenyl trichloromethyl carbinol was dissolved in 0.3 mole of pyridine. To the solution was dropwise added 0.22 mole of acetic acid anhydride with stirring. The resulting mixture was agitated for 2 hours. After completion of the reaction, the pyridine was distilled off at reduced pressure and the residue was washed with 50 ml of water. The crystals were filtered off to obtain ester of p-acetoxyphenyl trichloromethyl carbinol and acetic acid. Yield 98.5%, m.p. 152.5°-153° C.

Workup

  1. stirringThe resulting mixture was agitated for 2 hours
  2. customAfter completion of the reaction
  3. distillationthe pyridine was distilled off at reduced pressure
  4. washthe residue was washed with 50 ml of water
  5. filtrationThe crystals were filtered off

Sources & evidence

ORD record
ord-2a23154735db480495216a4696a8955f
Source dataset
uspto-grants-1985_10
Patent number
US04544766

Reaction notes

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