4-(Difluoromethoxy)-6-methylpyrimidin-2-amine → N-(2-difluoromethoxyphenyl-sulfonyl)-N'-(4-difluoromethoxy-6-methylpyrimidin-2-yl)-urea

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Reaction Steps

A mixture of 2.5 g of 2-difluoromethoxyphenylsulfonyl isocyanate, 1.75 g of 2-amino-4-difluoromethoxy-6-methyl-pyrimidine and 30 ml of absolute dioxane is stirred at a temperature of 70°-75° C. for 2 hours. The solution is evaporated and the residue is crystallised from ether to give 4.0 g of N-(2-difluoromethoxyphenyl-sulfonyl)-N'-(4-difluoromethoxy-6-methyl-pyrimidin-2-yl)-urea of melting point 163°-164° C.

Provenance & Evidence