Methyl Chloride → HCID 178493584, compound

Participants

Reaction Steps

19.2 g of 2-amino-4,6-dimethoxy-pyrimidine hydrochloride are heated at 150° C. for 2 hours, during which methyl chloride is detached to give 2-amino-4-hydroxy-6-methoxy-pyrimidine. 80 ml of 40% sodium hydroxide solution and 100 ml of dioxane are added, and 22 g of difluorochloromethane are passed in at 70°-75° in the course of 3/4 of an hour. The organic phase is separated off and concentrated to about 1/5 of its volume, the residue is poured into water and the solid precipitate is separated off to give 2.4 g of 2-amino-4-difluoromethoxy-6-methoxy-pyrimidine of melting point 106°-107° C.

Provenance & Evidence