Acrylonitrile → HCID 70477006, compound

Participants

Reaction Steps

To 100 ml of a solution of 6.0 g of N-(p-chlorobenzoyl)phenylglycine methyl ester in dichloromethane were added 1.6 g of acrylonitrile and 3.6 g of 1,8-diazabicyclo[5.4.0]-7-undecene followed by stirring at room temperature for 16 hours. The solvent was distilled off and 100 ml of ethyl ether were added to the resulting residue. The mixture was washed with two 100 ml portions of water, and the organic layer was separated off and dried over magnesium sulphate. The solvent was distilled off and the residue was recrystallized from diethyl ether, to give 5.8 g of the desired product as a colourless powder melting at 127°-128° C.

Provenance & Evidence