Acetic Anhydride → HCID 20263529, compound

HRID 464004Notes

Reaction equation

HRID 464004 reaction equation
[Cl:1][C:2]1[CH:19]=[CH:18][C:5]([C:6]([NH:8][C@:9]([CH2:14][CH2:15][C:16]#[N:17])([C:11]([OH:13])=[O:12])[CH3:10])=O)=[CH:4][CH:3]=1.C(OC(=O)C)(=O)C>C1C=CC=CC=1>[Cl:1][C:2]1[CH:19]=[CH:18][C:5]([C:6]2[O:12][C:11](=[O:13])[C:9]([CH2:14][CH2:15][C:16]#[N:17])([CH3:10])[N:8]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 54156959HCID 54156959, compound

Product 1

HCID 20263529HCID 20263529, compoundYield 80.1%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

2.8 g of N-(p-chlorobenzoyl)-2-(2-cyanoethyl)alanine and 2.0 g of acetic anhydride were dissolved in 30 ml of benzene and the solution was refluxed for one hour. The solvent was then distilled off and the resulting residue was recrystallized from di-isopropyl ether, to afford 2.1 g of the desired product as a colourless powder melting at 97°-98° C.

Workup

  1. temperaturethe solution was refluxed for one hour
  2. distillationThe solvent was then distilled off
  3. customthe resulting residue was recrystallized from di-isopropyl ether

Sources & evidence

ORD record
ord-09d642a950724ff1a57ab8402f3c7b25
Source dataset
uspto-grants-1985_10
Patent number
US04545942

Reaction notes

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