Ethyl orthoformate → HCID 20264251, compound

HRID 464117Notes

Reaction equation

HRID 464117 reaction equation
[NH2:1][N:2]1[C:7](=[O:8])[CH:6]=[C:5]([CH3:9])[N:4]=[C:3]1[NH:10][NH2:11].[CH:12](OCC)(OCC)OCC>C(O)CCC>[NH2:11][N:10]1[C:3]2=[N:4][C:5]([CH3:9])=[CH:6][C:7](=[O:8])[N:2]2[N:1]=[CH:12]1

Participants

4

Reactant 2

HCID 31214Ethyl orthoformateHCID 1492084HCID 1492084, compound

Product 1

HCID 20264251HCID 20264251, compound

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

A 2.4 g portion of 3-amino-2-hydrazino-6-methyl-4(3H)-pyrimidinone was dissolved in 100 ml of n-butanol by heating to the boiling point. A 20 ml portion of triethyl orthoformate was added and the solution was refluxed for 45 minutes. The solid was collected while the solution was hot, washed with ether and dried, giving 1.45 g of the desired intermediate, mp 202°-204°.

Workup

  1. temperatureby heating to the boiling point
  2. temperaturethe solution was refluxed for 45 minutes
  3. customThe solid was collected while the solution
  4. washwashed with ether
  5. customdried

Sources & evidence

ORD record
ord-f0a4b99aacb9439f8b4c8d7755bbaf66
Source dataset
uspto-grants-1985_10
Patent number
US04546181

Reaction notes

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