Ethyl 2-methylacetoacetate → 3-amino-2-hydrazino-5,6-dimethyl-4(3H)-pyrimidinone

HRID 464119Notes

Reaction equation

HRID 464119 reaction equation
Cl.[NH2:2][NH:3][C:4]([NH:6][NH2:7])=[NH:5].C[O-].[Na+].CC[O:13][C:14]([CH:16]([C:18]([CH3:20])=O)[CH3:17])=O>C(O)C>[NH2:2][N:3]1[C:14](=[O:13])[C:16]([CH3:17])=[C:18]([CH3:20])[N:5]=[C:4]1[NH:6][NH2:7]

Participants

5

Reactant 3

HCID 701Ethyl 2-methylacetoacetateHCID 10942334Sodium MethoxideHCID 178479531HCID 178479531, compound

Product 1

HCID 133817473-amino-2-hydrazino-5,6-dimethyl-4(3H)-pyrimidinoneYield 53.3%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 13.22 g of diaminoguanidine hydrochloride, 5.4 g of sodium methoxide, 7.2 g of ethyl-2-methyl acetoacetate and 100 ml of ethanol was reacted as described in Example 1, giving 4.5 g of 3-amino-2-hydrazino-5,6-dimethyl-4(3H)-pyrimidinone.

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-0e83c9b1e3394d6686e7390ae90bd8b3
Source dataset
uspto-grants-1985_10
Patent number
US04546181

Reaction notes

Loading…