Sodium borohydride → HCID 131714351, compound

Participants

Reaction Steps

The compound 10β-vinyl-estra-4-ene-3,17-dione described by Halpern et al, cited above is converted to 10β-vinyl-estra-4-ene-2β-ol-3,17-dione acetate by reaction with a molar excess of lead tetraacetate at 60° to 120° C. in acetic acid or under reflux in benzene for a reaction period of from 6 to 15 hours. This can be converted to 3-methylene-10β-vinyl-estra-4-ene-2-ol-17-one, compound 44, by the Wittig reaction. The latter compound may be reduced with sodium borohydride to produce compound 38, 3-methylene-10β-vinyl-estra-4-ene-2β, 17β-diol.

Provenance & Evidence