反应详情

A mixture of 90.5 g (0.25 mol) of 8-chloro-1-(2-chlorophenyl)-3,4-dihydro-4-[(dimethylamino)methylene]-5H-2-benzazepine-5-one, 100 g (0.96 mol) of formamidine acetate and 1.0 L of formamide was heated on a steam bath for 16 hr. The mixture was cooled to 0° and the resulting precipitate collected by filtration. The precipitate was washed with water and dried to constant weight to give off-white crystals mp 120°-121° C.

1. temperaturewas heated on a steam bath for 16 hr
2. temperatureThe mixture was cooled to 0°
3. filtrationthe resulting precipitate collected by filtration
4. washThe precipitate was washed with water
5. customdried to constant weight