HRID46421

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID176

Acetic Acid

C2H4O2

HCID14798

Sodium Hydroxide

HNaO

结构：COc1ccc(N=Nc2ccc(O)c(C(=O)Nc3ccc(OC)c(-c4nn(C(C)=O)c5cc(C)nn45)c3)c2)cc1

HCID136398787

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(N=Nc2ccc(O)c(C(=O)Nc3ccc(OC)c(-c4n[nH]c5cc(C)nn45)c3)c2)cc1

HCID178492408

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID887

Methanol

CH4O

溶剂HCID962

Water

H2O

PROCEDURE

实验过程

N-[3-(1-Acetyl-6-methyl-1H-pyrazolo[3,2-c]-s-triazol-3-yl)-4-methoxyphenyl]-2-hydroxy-5-(4-methoxyphenylazo) benzamide (1.4 g) was dissolved in methanol (100 ml) and a solution of sodium hydroxide (1.0 g) in water (30 ml) added. After stirring for 15 minutes the solution was acidified with glacial acetic acid when a gelatinous precipitate of the product appeared. This was removed by filtration, washed with water and crystallized in aqueous pyridine (850 mg; 66%), m.p. 295°-6°, λmax (methanol)=350 nm.

WORKUP

后处理

customThis was removed by filtration
washwashed with water
customcrystallized in aqueous pyridine (850 mg; 66%)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-39bc084246164093aa8cfdafc92b22fc
来源数据集: uspto-grants-1979_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04173478
来源说明: uspto-grants-1979_11

反应 SMILES

C([N:4]1[C:8]2=[CH:9][C:10]([CH3:12])=[N:11][N:7]2[C:6]([C:13]2[CH:14]=[C:15]([NH:21][C:22](=[O:40])[C:23]3[CH:28]=[C:27]([N:29]=[N:30][C:31]4[CH:36]=[CH:35][C:34]([O:37][CH3:38])=[CH:33][CH:32]=4)[CH:26]=[CH:25][C:24]=3[OH:39])[CH:16]=[CH:17][C:18]=2[O:19][CH3:20])=[N:5]1)(=O)C.[OH-].[Na+].C(O)(=O)C>CO.O>[CH3:20][O:19][C:18]1[CH:17]=[CH:16][C:15]([NH:21][C:22](=[O:40])[C:23]2[CH:28]=[C:27]([N:29]=[N:30][C:31]3[CH:32]=[CH:33][C:34]([O:37][CH3:38])=[CH:35][CH:36]=3)[CH:26]=[CH:25][C:24]=2[OH:39])=[CH:14][C:13]=1[C:6]1[N:7]2[N:11]=[C:10]([CH3:12])[CH:9]=[C:8]2[NH:4][N:5]=1