Dabco → HCID 13322005, compound

Participants

Reaction Steps

The crude 2-methylsulfonyl-3-thiophenesulfonyl isocyanate described above was dissolved in 100 ml of methylene chloride and 10 ml of this solution (0.3 g of crude isocyanate) was added to 200 mg of 4-methoxy-6-methyl-2-pyrimidinamine in methylene chloride containing a few crystals of DABCO. After stirring 3 days at room temperature, the precipitate was filtered and washed with ether to afford 250 mg of product, m.p. 204.5°-206° d. The IR spectrum showed a carbonyl absorption at 1680 cm-1 indicative of a sulfonylurea.

Provenance & Evidence