HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → alpha-(Aminomethyl)-2,2-dimethyl-1,3-dioxolane-4-methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 2,2-Dimethyl-4-(oxiran-2-YL)-1,3-dioxolane | HCID 13186827 | — |
| Product | alpha-(Aminomethyl)-2,2-dimethyl-1,3-dioxolane-4-methanol | HCID 11971028 | — |
Reaction Steps
A solution of 73.4 g of 2-(2,2-dimethyl-1,3-dioxolan-4-yl)ethylene oxide in 400 ml of 25% strength ammonia is heated in an autoclave for 4 hours to 130° C. The slightly yellowish solution is concentrated to dryness under vacuum; during this step, the residue crystallizes. 2-Amino-1-(2,2-dimethyl-1,3-dioxolan-4-yl)ethanol is re-crystallized from ethanol/ether, mp 94°-96° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04547357 |
| Source dataset | uspto-grants-1985_10 |
| ORD ID | ord-723c62d451c546768f0eec4af71fdfde |
| Source note | uspto-grants-1985_10 |