Triethylamine → Nictiazem

Participants

Reaction Steps

7 Grams (0.0188 mole) of the compound prepared under (A) were dissolved in 80 ml of anhydrous benzene, and the resulting solution was added with 8 ml (0.0574 mole) of triethylamine and 5 g (0.0281 mole) of nicotinoylchloride suspended in 20 ml of anhydrous benzene. The reaction mixture was heated for 24 hours on an oil bath at 55°-60° C. under stirring then, after cooling, it was twice washed with water and the organic phase was dried over sodium sulfate. The organic solvent was removed in vacuo until formation of a precipitate then, after complete precipitation, the obtained solid was recovered by filtration, washed with anhydrous diethyl ether and dried overnight at 70° C.

Provenance & Evidence