HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperazin-1-ylpropanol → 4-[6H-indolo[2,1-c][1,4]benzodiazepin-12-yl]piperazine-1-propanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperazin-1-ylpropanol | HCID 79207 | — |
| Reactant | 12-methylthio-6H-indolo[2,1-c][1,4]benzodiazepine | HCID 13505736 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-[6H-indolo[2,1-c][1,4]benzodiazepin-12-yl]piperazine-1-propanol | HCID 13505743 | — |
Reaction Steps
A mixture of 5.39 g of 12-methylthio-6H-indolo[2,1-c][1,4]benzodiazepine, the product of Example 1c., and 17 g of 1-piperazinepropanol in a pressurized bottle was heated to 220° C. overnight. The reaction mixture was dissolved in CH2Cl2 and then was washed with water. Removal of solvent in vacuo followed by recrystallization from EtOH gave the title compound, a colorless solid, mp 174°-175° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04547497 |
| Source dataset | uspto-grants-1985_10 |
| ORD ID | ord-9e79a1b5673c480b91e700511e00de92 |
| Source note | uspto-grants-1985_10 |