Ethanol → HCID 20262853, compound

Participants

Reaction Steps

4-(2-Chlorophenyl)-3-(ethoxycarbonyl)-3-(methoxycarbonyl)-6-methyl-2-[2-(piperazin-1-yl)ethoxymethyl]-1,4-dihydropyridine (0.7 g) was dissolved in 10 ml of ethanol and converted to the oxalate salt by addition of a solution of 0.15 g of oxalic acid in 5 ml of ethanol. To this suspension was added 0.12 g of 2-ethoxypyrroline and the mixture was refluxed for 18 hours. The reaction mixture was then filtered through "Solka-floc" (Trade Mark) and evaporated to dryness. The resultant solid was basified with aqueous sodium carbonate solution and extracted with methylene chloride to give a white solid. After two crystallizations from diisopropylether, there was obtained 0.1 g of the title compound, m.p. 104°.

Provenance & Evidence