Ethyl orthoformate → HCID 13385681, compound

HRID 464255Notes

Reaction equation

HRID 464255 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([NH:12][NH2:13])[C:6]([O:14][CH3:15])=[N:5]2.[CH:16](OCC)(OCC)OCC>>[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]1[CH:16]=[N:13][N:12]=[C:7]1[C:6]([O:14][CH3:15])=[N:5]2

Participants

3

Reactant 2

HCID 31214Ethyl orthoformateHCID 13385671HCID 13385671, compound

Product 1

HCID 13385681HCID 13385681, compound

Conditions

Temperature
100 °C

Procedure

A mixture consisting of 15 g. (0.072 mole) of 6-fluoro-2-hydrazino-3-methoxyquinoxaline and 250 ml. of triethyl orthoformate was heated with mechanical stirring in a preheated oil both at 100° C. overnight (~16 hours). The resulting mixture was then cooled to room temperature, and the precipitate which formed was subsequently recovered by means of suction filtration and washed with ethanol to ultimately afford 11.3 g (72%) of pure 7-fluoro-4-methoxy-[1,2,4]triazolo[4,3-a]quinoxaline, m.p. 245°-246° C. (decomp.).

Workup

  1. temperatureThe resulting mixture was then cooled to room temperature
  2. customthe precipitate which formed
  3. filtrationwas subsequently recovered by means of suction filtration
  4. washwashed with ethanol to ultimately afford 11.3 g (72%) of pure 7-fluoro-4-methoxy-[1,2,4]triazolo[4,3-a]quinoxaline, m.p. 245°-246° C. (decomp.)

Sources & evidence

ORD record
ord-4b34ac898b2049818b978036a17103c2
Source dataset
uspto-grants-1985_10
Patent number
US04547501

Reaction notes

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