Diethylamine → 4-Diethylamino-1-n-propyl-[1,2,4]triazolo[4,3-a]quinoxaline

HRID 464296Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 464296
Cl[C:2]1[C:3]2[N:4]([C:12]([CH2:15][CH2:16][CH3:17])=[N:13][N:14]=2)[C:5]2[C:10]([N:11]=1)=[CH:9][CH:8]=[CH:7][CH:6]=2.[CH2:18]([NH:20][CH2:21][CH3:22])[CH3:19]>CN(C)C=O>[CH2:18]([N:20]([CH2:21][CH3:22])[C:2]1[C:3]2[N:4]([C:12]([CH2:15][CH2:16][CH3:17])=[N:13][N:14]=2)[C:5]2[C:10]([N:11]=1)=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH3:19]

Komponenten

4

Edukt 2

HCID 8021DiethylamineHCID 133857074-Chloro-1-propyl[1,2,4]triazolo[4,3-a]quinoxaline

Produkt 1

HCID 133857194-Diethylamino-1-n-propyl-[1,2,4]triazolo[4,3-a]quinoxalineAusbeute 78 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

4-Chloro-1-n-propyl-[1,2,4]-triazolo[4,3-a]quinoxaline (1.23 g., 0.005 mole), the product of Example 5, and 1.1 g. (0.015 mole) of diethylamine in N,N-dimethylformamide (15 ml.) were stirred at room temperature for 2 hours. The reaction mixture was then poured over ice. The precipitate was removed by filtration, washed with water and air dried. Recrystallization (twice) from ethanol/water afforded 1.1 g. (78% yield) of pure 4-diethylamino-1-n-propyl-[1,2,4]triazolo[4,3-a]quinoxaline, m.p. 92°-94° C. Mass spectrum: m/e, 283 (P).

Aufarbeitung

  1. additionThe reaction mixture was then poured over ice
  2. customThe precipitate was removed by filtration
  3. washwashed with water and air
  4. customdried
  5. customRecrystallization (twice) from ethanol/water
  6. customafforded 1.1 g

Quellen und Nachweise

ORD-Eintrag
ord-baa8989422304f04894d191ecf3f7aaa
Quelldatensatz
uspto-grants-1985_10
Patentnummer
US04547501

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