HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methylthio-5-(2-chlorobenzyl)pyrimid-4-one → 2-[3-(N-methyl-N-pyrid-2-ylamino)propylamino]-5-(2-chlorobenzyl)pyrimid-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methylthio-5-(2-chlorobenzyl)pyrimid-4-one | HCID 12951520 | — |
| Reactant | N-(3-Aminopropyl)-N-methylpyridin-2-amine | HCID 20262876 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 2-[3-(N-methyl-N-pyrid-2-ylamino)propylamino]-5-(2-chlorobenzyl)pyrimid-4-one | HCID 53884870 | — |
Reaction Steps
2-[N-(3-aminopropyl)-N-methylamino]pyridine (0.74 g) and 2-methylthio-5-(2-chlorobenzyl)pyrimid-4-one (1.0 g) were heated together under reflux in pyridine (2.5 ml) for 28 hr. After stripping, the residue was recrystallised twice from ethanol/water to give 2-[3-(N-methyl-N-pyrid-2-ylamino)propylamino]-5-(2-chlorobenzyl)pyrimid-4-one 0.5H2O, 0.87 g (59%) mp 47°-49° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04547506 |
| Source dataset | uspto-grants-1985_10 |
| ORD ID | ord-e0fb1e1b153d46f897ad2222268e7983 |
| Source note | uspto-grants-1985_10 |