HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methylthio-5-(3-chlorobenzyl)pyrimid-4-one → 2-[3-(N-methyl-N-pyrid-2-ylamino) propylamino]-5-(3-chlorobenzyl)pyrimid-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methylthio-5-(3-chlorobenzyl)pyrimid-4-one | HCID 12951512 | — |
| Reactant | N-(3-Aminopropyl)-N-methylpyridin-2-amine | HCID 20262876 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 2-[3-(N-methyl-N-pyrid-2-ylamino) propylamino]-5-(3-chlorobenzyl)pyrimid-4-one | HCID 54313049 | — |
Reaction Steps
2-[N-(3-aminopropyl)-N-methylamino]pyridine (0.74 g) and 2-methylthio-5-(3-chlorobenzyl)pyrimid-4-one (0.8 g) were heated together under reflux in pyridine (2.5 ml) for 26 hr. After stripping, the residue was recrystallised three times from ethanol/water to give 2-[3-(N-methyl-N-pyrid-2-ylamino) propylamino]-5-(3-chlorobenzyl)pyrimid-4-one 1H2O, 0.7 g (58%) mp 105°-7° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04547506 |
| Source dataset | uspto-grants-1985_10 |
| ORD ID | ord-8a21201606f341b3858476ff94d9ff7e |
| Source note | uspto-grants-1985_10 |