HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(3-Aminopropyl)-N-methylpyridin-2-amine → 2-[3-(N-methyl-N-pyrid-2-ylamino) propylamino]-5-(4-fluorobenzyl)-pyrimid-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(3-Aminopropyl)-N-methylpyridin-2-amine | HCID 20262876 | — |
| Reactant | 5-(4-Fluorobenzyl)-2-methylthio-4-pyrimidone | HCID 20262878 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 2-[3-(N-methyl-N-pyrid-2-ylamino) propylamino]-5-(4-fluorobenzyl)-pyrimid-4-one | HCID 54442636 | — |
Reaction Steps
2-[N-(3-aminopropyl)-N-methylamino]pyridine (1.0 g) and 2-methylthio-5-(4-fluorobenzyl)pyrimid-4-one (1.25 g) were heated together under reflux in pyridine (3 ml) for 24 hr. The mixture was stripped and the residue recrystallised twice from ethanol/water to give 2-[3-(N-methyl-N-pyrid-2-ylamino) propylamino]-5-(4-fluorobenzyl)-pyrimid-4-one 0.5H2O, 1.2 g (64%) mp ca. 70° C. (softens).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04547506 |
| Source dataset | uspto-grants-1985_10 |
| ORD ID | ord-bd035e82c99042a7af36694023ca2e13 |
| Source note | uspto-grants-1985_10 |