5-(4-Methoxybenzyl)-2-methylthio-4-pyrimidone → 2-[3-(N-propyl-N-pyrid-2-ylamino)propylamino]-5-(4-methoxybenzyl)pyrimid-4-one

Participants

Reaction Steps

2-[N-(3-aminopropyl)-N-propylamino]pyridine (0.88 g) and 2-methylthio-5-(4-methoxybenzyl)pyrimid-4-one (1.0 g) were fused together on an oil bath at 160° C. for 2.5 hr. On cooling the residue was crystallised from ethanol/water and again from acetone/water to give 2-[3-(N-propyl-N-pyrid-2-ylamino) propylamino]-5-(4-methoxybenzyl)pyrimid-4-one 1H2O, 1.27 g (79%) mp indeterminate.

Provenance & Evidence