HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-[N-(3-aminopropyl)-N-propylamino]pyridine → 2-[3-(N-propyl-N-pyrid-2-ylamino) propylamino]-5-(4-fluorobenzyl)pyrimid-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-[N-(3-aminopropyl)-N-propylamino]pyridine | HCID 20186605 | — |
| Reactant | 5-(4-Fluorobenzyl)-2-methylthio-4-pyrimidone | HCID 20262878 | — |
| Product | 2-[3-(N-propyl-N-pyrid-2-ylamino) propylamino]-5-(4-fluorobenzyl)pyrimid-4-one | HCID 53834244 | — |
Reaction Steps
2-[N-(3-aminopropyl)-N-propylamino]pyridine (1.16 g) and 2-methylthio-5-(4-fluorobenzyl)pyrimid-4-one (1.25 g) were fused together on an oil bath at 160° C. for 5 hr. On cooling the residue was crystallised twice from ethanol and finally from ethanol/water to give 2-[3-(N-propyl-N-pyrid-2-ylamino) propylamino]-5-(4-fluorobenzyl)pyrimid-4-one 1.2H2O, 0.75 g (36%) mp 107°-9° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04547506 |
| Source dataset | uspto-grants-1985_10 |
| ORD ID | ord-703324f891a84554a3d2023d54f67e11 |
| Source note | uspto-grants-1985_10 |