Sodium Hydroxide → Maltol

Temperature

90 °C

2-(1-hydroxyethyl)-3-methoxy-furan (0.350 g, 2.5 mmole) in 4 ml of methanol and 1 ml of water was added to a solution of 2 ml of methanol and 5 ml of water as chlorine gas (2.5 mmoles) was added to the well stirred reaction. The temperature of the reaction was kept below -10° C. at all times. Following the addition the reaction was heated to 90° C. for 3 hours. After cooling, the reaction was adjusted to a pH 2.2 with 50% NaOH solution, the reaction was extracted with chloroform and the chloroform concentrated to yield maltol.

1. additionwas added to the well
2. customreaction
3. customwas kept below -10° C. at all times
4. additionthe addition the reaction
5. temperatureAfter cooling
6. extractionthe reaction was extracted with chloroform
7. concentrationthe chloroform concentrated

ORD record

ord-cab21f48b93249e88dbacd4669c7c946

Source dataset

uspto-grants-1979_11

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04173572