HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-[N-(4-aminobutyl)-N-propylamino]pyridine → 2-[4-(N-propyl-N-pyrid-2-ylamino)butylamino]5-(4-fluorobenzyl)pyrimid-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-[N-(4-aminobutyl)-N-propylamino]pyridine | HCID 20186617 | — |
| Reactant | 5-(4-Fluorobenzyl)-2-methylthio-4-pyrimidone | HCID 20262878 | — |
| Product | 2-[4-(N-propyl-N-pyrid-2-ylamino)butylamino]5-(4-fluorobenzyl)pyrimid-4-one | HCID 53668296 | — |
Reaction Steps
2-[N-(4-aminobutyl)-N-propylamino]pyridine (1.24 g) and 2-methylthio-5-(4-fluorobenzyl)pyrimid-4-one (1.25 g) were fused together on an oil bath at 160° C. for 2.5 hr. On cooling the residue was crystallised twice from ethanol/water to give 2-[4-(N-propyl-N-pyrid-2-ylamino)butylamino]5-(4-fluorobenzyl)pyrimid-4-one 1.25H2O, 0.56 g (26.%) mp indeterminate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04547506 |
| Source dataset | uspto-grants-1985_10 |
| ORD ID | ord-cadd9e8859ab4e4e8a5d4d2efe65cbdc |
| Source note | uspto-grants-1985_10 |