HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methylthio-5-cyclohexylmethylpyrimid-4-one → 2-[3-(N-propyl-N-pyrid-2-ylamino)propylamino]-5-cyclohexylmethylpyrimid-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methylthio-5-cyclohexylmethylpyrimid-4-one | HCID 12783837 | — |
| Reactant | 2-[N-(3-aminopropyl)-N-propylamino]pyridine | HCID 20186605 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 2-[3-(N-propyl-N-pyrid-2-ylamino)propylamino]-5-cyclohexylmethylpyrimid-4-one | HCID 20262888 | — |
Reaction Steps
2-[N-(3-aminopropyl)-N-propylamino]pyridine (1.09 g) and 2-methylthio-5-cyclohexylmethylpyrimid-4-one (0.9 g) were heated together under reflux in pyridine (2.5 ml) for 28 hr. After stripping, the residue was triturated with ether and crystallized twice from ethanol/water to give 2-[3-(N-propyl-N-pyrid-2-ylamino)propylamino]-5-cyclohexylmethylpyrimid-4-one 0.5 H2O, 1.14 g (78%) m.p. 103°-106° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04547506 |
| Source dataset | uspto-grants-1985_10 |
| ORD ID | ord-c89ba68b10ea477c817b0d2de2c4b65b |
| Source note | uspto-grants-1985_10 |