反应详情

Substituting ethyl iodide (10.31 g) for n-propyl iodide and using the corresponding molar proportions of the other reagents in the method of example 15(i) gave 2-[N-(3-aminopropyl)-N-ethylamino]pyridine (2.32 g) as an oil. (ii) 2-[N-(3-aminopropyl)-N-ethylamino]pyridine (1.0 g) and 2-methylthio-5-(4-chlorobenzyl)pyrimid-4-one (0.99 g) were heated together under reflux in pyridine (2.5 ml) for 28 hr. After stripping the residue was crystallized from ethanol and recrystallized from ethanol/water to give 2-[3-(N-ethyl-N-pyrid-2-ylamino)propylamino]-5-(4-chlorobenzyl)pyrimid-4-one 0.9 H2O, 1.23 g (79%) m.p. 86°-89° C.

1. customwas crystallized from ethanol
2. customrecrystallized from ethanol/water