反应详情

To a solution of 170 ml of 2M phosgene (0.34 mole) stirred at 15° C. was added 109.2 g (0.34 mole) of 1-benzyl-3-(2,6-dichlorophenoxy)pyrrolidine in 300 ml of benzene. The color turned from yellow to deep amber. For convenience, the solution was allowed to stir for 72 hr, then concentrated to give a deep amber colored viscous oil. The oil was triturated with 1.6 liters of 30/60 petroleum ether. The petroleum ether wash was cooled to give 101.5 g of nearly pure title compound containing a trace of benzyl chloride. The yield was nearly quantitative.

1. concentrationconcentrated
2. customto give a deep amber colored viscous oil
3. customThe oil was triturated with 1.6 liters of 30/60 petroleum ether
4. washThe petroleum ether wash
5. temperaturewas cooled