Phosgene → HCID 20262995, compound

Participants

Reaction Steps

To a solution of 9.5 g (0.097 mole) of phosgene in 200 ml of methylene chloride under nitrogen gas was added dropwise with stirring, 30.2 g (0.88 mole) of 1-benzyl-3-phenoxypyrrolidine in 100 ml of methylene chloride over a 45 minute period. The reaction mixture was stirred additionally for 20 minutes. The reaction mixture was concentrated in vacuo to give 31.9 g of oil. The oil was triturated with boiling 30/60 petroleum ether and the mixture was cooled. The ether layer was decanted off and the trituration in petroleum ether procedure was repeated 3 times. The oil contained a trace of benzyl chloride as indicated by thin-layer chromatography.

Provenance & Evidence