Methyl Isocyanate → HCID 13194666, compound

HRID 464437Notes

Reaction equation

HRID 464437 reaction equation
[Cl:1][C:2]1[CH:14]=[CH:13][C:5]([C:6]([NH:8][N:9]=[C:10]([CH3:12])[CH3:11])=[O:7])=[CH:4][CH:3]=1.[CH3:15][N:16]=[C:17]=[O:18]>CN(C)C.CC(C)=O>[Cl:1][C:2]1[CH:14]=[CH:13][C:5]([C:6]([N:8]([C:17](=[O:18])[NH:16][CH3:15])[N:9]=[C:10]([CH3:11])[CH3:12])=[O:7])=[CH:4][CH:3]=1

Participants

5

Reactant 2

HCID 12228Methyl IsocyanateHCID 3516324-chloro-N-(propan-2-ylideneamino)benzamide

Product 1

HCID 13194666HCID 13194666, compoundYield 95.2%

Reagents, catalysts & solvents 2

HCID 1146TrimethylamineCatalystHCID 180AcetoneSolvent

Procedure

10.5 g of 1-p-chlorobenzoyl-2-isopropylidene hydrazine, 2.9 g of methyl isocyanate and 100 ml of acetone were placed in a 200 ml round-bottom flask, and 3 drops of trimethylamine were added thereto. The mixture was stirred at room temperature for one hour. The separated crystalline mass was recovered to obtain 12.7 g (95%) of 1-p-chlorobenzoyl-1-methylcarbamoyl-2-isopropylidene hydrazine as white crystals having a melting point of 119°-123° C.

Workup

  1. customThe separated crystalline mass was recovered

Sources & evidence

ORD record
ord-d71a98a3e7a84801bf3eac48f54cf1f9
Source dataset
uspto-grants-1985_10
Patent number
US04547524

Reaction notes

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