HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluenesulfonic acid → (1R,cis)2,2-dimethyl-3-(pentyloxycarbonyl-ethynyl)-cyclopropane-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | tert.-butyl(1R,cis)2,2-dimethyl-3-[pentyloxycarbonylethynyl]cyclopropane-carboxylate | HCID 57192866 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | (1R,cis)2,2-dimethyl-3-(pentyloxycarbonyl-ethynyl)-cyclopropane-carboxylic acid | HCID 18599579 | 112% |
Reaction Steps
A mixture of 5.24 g of the product of Step A, 50 ml of toluene and 250 mg of p-toluene sulfonic acid was refluxed until gas evolution ceased and was then evaporated to dryness under reduced pressure to obtain 4.8 g of crude (1R,cis)2,2-dimethyl-3-(pentyloxycarbonyl-ethynyl)-cyclopropane-carboxylic acid which was used as is for the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04547522 |
| Source dataset | uspto-grants-1985_10 |
| ORD ID | ord-b7e3141629f848c2bf931eec41b1927f |
| Source note | uspto-grants-1985_10 |