HCID 131714385, compound → HCID 131714384, compound

Participants

Reaction Steps

To a solution of FMOC-Lys(Boc)-Asp(O-t-Bu)-OBzl (37) (5.0 g, 6.9 M) in dimethylformamide (50 ml) was added 10 percent Pd/C. (500 mg). The mixture was hydrogenated for 5 hrs at 50 psi H2. The solids were removed by filtration and the solvents removed under reduced pressure. This material was chromatographed on silica gel, eluting with acetone/methylene chloride/acetic acid 25/74/1 to give 4.3 g (98 percent) of 40 which was used without further characterization.

Provenance & Evidence