HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Amino-1-cyclopropyl-5-nitroso-2,4(1H,3H)-pyrimidinedione → 1-cyclopropyl-5,6-diamino-2,4-(1H,3H)-pyrimidinedione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Amino-1-cyclopropyl-5-nitroso-2,4(1H,3H)-pyrimidinedione | HCID 54223493 | — |
| Catalyst | Adams' catalyst | HCID 345198 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-cyclopropyl-5,6-diamino-2,4-(1H,3H)-pyrimidinedione | HCID 53690076 | — |
Reaction Steps
15.9 g of 6-amino-1-cyclopropyl-5-nitroso-2,4-(1H,3H)-pyrimidinedione (III) was catalytically hydrogenated in 1 liter of DMF and in the presence of 0.1 g PtO2 for 4 hours and at room temperature and at a pressure of 200 kPa. The catalyst and the crystals were filtered off and washed with ethanol. Yield 12.9 g (87%) (IV).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04548818 |
| Source dataset | uspto-grants-1985_10 |
| ORD ID | ord-38416d6622414c3fb0ce5db55fb35fdb |
| Source note | uspto-grants-1985_10 |