Diethyl Ether → 1H-Purine-2,6-dione, 3,7-dihydro-3-(cyclohexylmethyl)-

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Reaction Steps

2 g of 5,6-diamino-1-cyclohexylmethyl-2,4-(1H,3H)-pyrimidine dione (XXII) was refluxed in 10 ml of formic acid for 1 h. 5 ml of chloroform was added and ether was then added slowly. The received crystals were filtered off. Yield 2.1 g (XXIII). The amide (XXIII) was refluxed in 15 ml of 2N NaOH for 1 hour and then neutralized with 5N HCl. Yield 1.7 g (XXIV) NMR (see Table I). ##STR12##

Provenance & Evidence