Ethanol → 1H-Purine-2,6-dione, 3,7-dihydro-3-(2,2-dimethylpropyl)-

HRID 464608Notes

Reaction equation

HRID 464608 reaction equation
[NH2:1][C:2]1[C:3](=[O:15])[NH:4][C:5](=[O:14])[N:6]([CH2:9][C:10]([CH3:13])([CH3:12])[CH3:11])[C:7]=1[NH2:8].[CH2:16](O)C>C(N)=O>[CH3:13][C:10]([CH3:11])([CH3:12])[CH2:9][N:6]1[C:7]2[N:8]=[CH:16][NH:1][C:2]=2[C:3](=[O:15])[NH:4][C:5]1=[O:14]

Participants

4

Reactant 2

HCID 702EthanolHCID 54164473HCID 54164473, compound

Product 1

HCID 30590001H-Purine-2,6-dione, 3,7-dihydro-3-(2,2-dimethylpropyl)-

Reagents, catalysts & solvents 1

HCID 713FormamideSolvent

Procedure

4.0 g of XXVIII was refluxed in 20 ml of formamide for 30 minutes. After cooling 30 ml of ethanol was added and the yellow crystals were filtered off and recrystallized from 15 ml of DMF. Yield 2.0 g (XXIX) NMR (see Table I). ##STR13##

Workup

  1. additionwas added
  2. filtrationthe yellow crystals were filtered off
  3. customrecrystallized from 15 ml of DMF

Sources & evidence

ORD record
ord-b1e004199de94c14b160d6b7cab6abfe
Source dataset
uspto-grants-1985_10
Patent number
US04548818

Reaction notes

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