Acetic Acid → HCID 20217052, compound

HRID 464612Notes

Reaction equation

HRID 464612 reaction equation
[CH:1]1([N:5]2[C:10]([NH2:11])=[C:9]([NH2:12])[C:8](=[O:13])[NH:7][C:6]2=[O:14])[CH2:4][CH2:3][CH2:2]1.[C:15](O)(=O)[CH3:16]>>[CH:1]1([N:5]2[C:10]3[N:11]=[C:15]([CH3:16])[NH:12][C:9]=3[C:8](=[O:13])[NH:7][C:6]2=[O:14])[CH2:2][CH2:3][CH2:4]1

Participants

3

Reactant 2

HCID 176Acetic AcidHCID 54485518HCID 54485518, compound

Product 1

HCID 20217052HCID 20217052, compound

Procedure

A solution of 2.2 g of 1-cyclobutyl-5,6-diamino-2,4-(1H,3H)-pyrimidinedione (X) in 10 ml of acetic acid was refluxed for 2 hours. The solution was evaporated. The received oil was refluxed in 30 ml of 5N NaOH for 1 hour and then neutralized with 5 N HCl. The crystals were filtered off and recrystallized from 100 ml ethanol. Yield 0.4 g (18%) (XXXVII) NMR (see Table I).

Workup

  1. customThe solution was evaporated
  2. temperatureThe received oil was refluxed in 30 ml of 5N NaOH for 1 hour
  3. filtrationThe crystals were filtered off
  4. customrecrystallized from 100 ml ethanol

Sources & evidence

ORD record
ord-51896c875b1943308218dc12044c7b58
Source dataset
uspto-grants-1985_10
Patent number
US04548818

Reaction notes

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