HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → 3,7-dihydro-8-methyl-3-propyl-1H-purine-2,6-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | 5,6-Diamino-1-propyl-1,2,3,4-tetrahydropyrimidine-2,4-dione | HCID 10631341 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 3,7-dihydro-8-methyl-3-propyl-1H-purine-2,6-dione | HCID 20217050 | — |
Reaction Steps
A solution of 22.6 g of 5,6-diamino-1-propyl-2,4-(1H,3H)-pyrimidinedione in 50 ml of acetic acid was refluxed for 2 hours. 30 ml of ethanol was added. The received crystals were filtered off. Yield 19.8 g. The amide was refluxed in 80 ml of 2N NaOH for 2 hours and then neutralized with 5N HCl. The crystals were filtered off and recrystallized from 2.1 l ethanol. Yield 9.8 g (38%) (XXXXVI) NMR (see Table I).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04548818 |
| Source dataset | uspto-grants-1985_10 |
| ORD ID | ord-6342188adb714c58b43464f01a451963 |
| Source note | uspto-grants-1985_10 |