Dimethyl N-cyanodithioiminocarbonate → HCID 178469304, compound

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Reaction Steps

A solution of 2-(2-aminoethyl)-5-{[4-(2,3-dichlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridin-2-yl]methoxymethyl}tetrazole (1.04 g) and dimethyl N-cyanoimidodithiocarbonate (0.30 g) in propan-2-ol (10 ml) was heated under reflux for 16 hours and then evaporated. The residual oil was triturated with hexane containing a small amount of methanol and the resulting solid was collected washed with hexane and dried to give 5-{[4-(2,3-dichlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridin-2-yl]methoxymethyl}-2-[2-(3-cyano-2-methyl-1-isothioureido)ethyl]tetrazole (0.75 g), m.p. 78°-80° C. Found: C,48.53; H,4.93; N,17.60. C25H28Cl2N8O5S requires C,48.23; H,4.34; N,18.00%.

Provenance & Evidence