HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethyl Sulfoxide → 5-Nitro-2-(2,2,2-trifluoroethoxy)pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethyl Sulfoxide | HCID 679 | — |
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | 2,2,2-Trifluoroethanol | HCID 6409 | — |
| Reactant | 2-Chloro-5-nitropyridine | HCID 78308 | — |
| Solvent | Water | HCID 962 | — |
| Product | 5-Nitro-2-(2,2,2-trifluoroethoxy)pyridine | HCID 613718 | — |
Reaction Steps
2-Chloro-5-nitropyridine (9.5 grams), 2,2,2-trifluoroethanol (6.0 grams), and lithium hydroxide (4.0 grams) were mixed in 50 ml. of DMSO and stirred overnight (about 18 hours) at room temperature. The reaction mixture was then poured into water and the product was separated by filtration. It was crystallized from ethyl acetate-hexanes, yield 5.0 grams, m.p., 35°-37° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04173639 |
| Source dataset | uspto-grants-1979_11 |
| ORD ID | ord-558bb867ab5c4bd4a3b4e2b03e7cc939 |
| Source note | uspto-grants-1979_11 |