HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Chloride → 2-(2,2,2-trifluoroethoxy)pyridin-3-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | 5-Nitro-2-(2,2,2-trifluoroethoxy)pyridine | HCID 613718 | — |
| Catalyst | Iron | HCID 23925 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-(2,2,2-trifluoroethoxy)pyridin-3-amine | HCID 16785301 | 23.1% |
Reaction Steps
2-(2,2,2-Trifluoroethoxy)-5-nitropyridine (5.0 grams), powdered iron (15 grams), and ammonium chloride (25 grams) were refluxed in 3A ethanol until TLC detected no starting material (about 4 hours). The reaction mixture was filtered, washed with water, and solvents removed, yielding 1.0 gram of the product as a thin brownish liquid. NMR confirmed the identity of the product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04173639 |
| Source dataset | uspto-grants-1979_11 |
| ORD ID | ord-3817a0ce2dd540c5b34efa23b714c16d |
| Source note | uspto-grants-1979_11 |