反应详情

A mixture of 47.1 gm of ethyl N-[3-(2-guanidino-4-thiazolyl)-phenyl]-carbamate hydrobromide, 210 ml of ethanol and 210 ml of a 50% potassium hydroxide solution was refluxed for 15 minutes. After cooling, the white precipitate which had formed was filtered off, dissolved in water and carefully acidified with hydrochloric acid. The resulting solution was made alkaline with an excess of sodium hydroxide solution, and the precipitate formed thereby was filtered off, washed with water and dried, yielding 20 gm of the title compound, m.p. 222°-224° C.

1. temperaturewas refluxed for 15 minutes
2. temperatureAfter cooling
3. customthe white precipitate which had formed
4. filtrationwas filtered off
5. dissolutiondissolved in water
6. customthe precipitate formed
7. filtrationthereby was filtered off
8. washwashed with water
9. customdried