Dimethylformamide diethylacetal → HCID 178484243, compound

HRID 464709Notes

Reaction equation

HRID 464709 reaction equation
[NH:1]([C:5]1[S:6][CH:7]=[C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([NH2:16])[CH:11]=2)[N:9]=1)[C:2]([NH2:4])=[NH:3].C(O[CH:20](OCC)[N:21]([CH3:23])[CH3:22])C>>[CH3:20][N:21]([CH3:23])[CH:22]=[N:16][C:12]1[CH:13]=[CH:14][CH:15]=[C:10]([C:8]2[N:9]=[C:5]([NH:1][C:2]([NH2:4])=[NH:3])[S:6][CH:7]=2)[CH:11]=1

Participants

3

Reactant 2

HCID 70913Dimethylformamide diethylacetalHCID 1785126111-(4-(3-Aminophenyl)thiazol-2-yl)guanidine

Product 1

HCID 178484243HCID 178484243, compoundYield 77.7%

Procedure

A solution of 2.5 gm of 2-guanidino-4-(3-amino-phenyl)-thiazole in 7.5 gm of N,N-dimethylformamide diethylacetal was stirred at room temperature for 2 days. Addition of diethyl precipitated a solid which was filtered off and dried, yielding 2.4 gm of the title compound.

Workup

  1. additionAddition of diethyl
  2. customprecipitated a solid which
  3. filtrationwas filtered off
  4. customdried

Sources & evidence

ORD record
ord-6455c56bba4841cbbf642d05251388ff
Source dataset
uspto-grants-1985_10
Patent number
US04548944

Reaction notes

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