HCID 70479432, compound → HCID 57131503, compound

Participants

Reaction Conditions

Reaction Steps

32 g (0.072 moles) of benzyl 2-[(2,6-dichlorophenyl)amino]phenylacetoxyacetate prepared above were dissolved in 1000 ml of acetic acid, and the resulting mixture was mixed with 5 g of Pd/C 10% and then hydrogenated at a pressure of 3 atmospheres under heating to a temperature of 40° C. for a period of 10 hours. The catalyst was filtered, and the resulting solution was concentrated and then washed with toluene to remove acetic acid. The product was then recrystallized from cyclohexane, thus obtaining 13 g (50%) of 2-[(2,6-dichlorophenyl)amino]phenylacetoxyacetic acid, in the form of white crystals having a melting point of 149°-150° C., Rf=0.51 (acetone 100/acetic acid 2.5). Spectral data and elemental analysis of the product were as follows.

Provenance & Evidence