HuagongsheHuagongshe Chemistry Print Report · For research reference only
Nitromethane → 4-Nitro-3-(3,4-dichlorophenyl)butanoic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Nitromethane | HCID 6375 | — |
| Reactant | 1,1,3,3-Tetramethylguanidine | HCID 66460 | — |
| Reactant | Methyl 3-(3,4-dichlorophenyl)prop-2-enoate | HCID 54151376 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 4-Nitro-3-(3,4-dichlorophenyl)butanoic acid methyl ester | HCID 21472502 | — |
Reaction Steps
A mixture of 300 g of 3,4-dichlorocinnamic acid methyl ester, 400 g of nitromethane and 26 g of tetramethylguanidine is allowed to stir for 72 hours. The solution is diluted with ethyl ether and aqueous hydrochloric acid solution (1 N, 1 liter) is added. The organic layer is separated, dried over anhydrous magnesium sulfate, and evaporated to give 4-nitro-3-(3,4-dichlorophenyl)butanoic acid methyl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04548947 |
| Source dataset | uspto-grants-1985_10 |
| ORD ID | ord-a5462e0316cc4d8eaf0de03e347fea08 |
| Source note | uspto-grants-1985_10 |